Propolis – amazing stuff made by bees from nature

Propolis is a resinous material collected by bees from plant buds and exudates, mixed with bee enzymes, pollen and wax. The term propolis derives from two Greek words, pro (which means for or in defense of) and polis (which means the city), reflecting its application by bees to help protect the hive. The chemical composition of propolis is directly determined by the geographical location, but polyphenols, phenolic acids, caffeic acid phenethyl ester (CAPE), flavonoids, diterpenes, amino acids, vitamins and minerals are predominant constituents.

“Poplar-type” propolis has the widest spread in the world, in the temperate zones from Europe, Asia, or North America. Different species of Pine (Pinus spp.), Prunus spp., Acacia spp. and also birch (Betula pendula), horsechestnut (Aesculus hippocastanum), and willow (Salix spp) are also important sources of resins for poplar-type propolis(1). New Zealand propolis is usually of the poplar-type, obtained by honey bees largely from exudates of poplar.

Propolis is reported to possess a huge array of biological properties, with more than 270 review papers alone published in the scientific literature. Key actions include antimicrobial, anti-inflammatory, antioxidant, anti-cancer, anti-diabetic as well as cardioprotective and neuroprotective activities. Other potentially useful properties continue to be reported by researchers, on a regular basis.

Antiviral:

Immune modulatory effects have been assigned to propolis for many centuries, with effects on both the cellular and humoral immune responses, including increased antibody production(2, 3).

In the early 1990s, propolis flavonoids were shown to reduce of the infectivity and replication of some herpes virus, adenovirus, rotavirus, and coronavirus strains(4). Potent activity against the herpes simplex type 1 virus has been reported particularly for an ethanolic propolis extract(5). Antiviral activity and a dose-dependent reduction in influenza virus yields in the bronchoalveolar lavage fluids of lungs, and prolonged survival times of influenza infected mice, has been reported following administration of 2 and 10mg/kg doses of propolis three times daily(6). Improved platelet counts and a shortened duration of hospitalization in patients with the Dengue Fever virus, was seen following seven days propolis administration(7).  Enhanced immune responses including lymphocyte proliferation and antibody production after administration of a recombinant HIV-1 vaccine to mice, were recently reported when propolis was used as an adjuvant(8). These and its anti-inflammatory properties, suggest the possibility of using it as an adjuvant to other vaccines(3).

When I reviewed potential phytomedicinal treatment options for COVID-19 early last year, propolis was one of the most compelling agents I evaluated, based upon the published literature at the time. Since then and with research into plant-derived treatments having received increased funding, this view is now further supported by in vitro and clinical studies(9-16).

Brazilian researchers have just published the results of a controlled clinical trial in which propolis was given as an adjunct treatment in hospitalized COVID-19 patients(13). Three groups of 40 patients were assigned to receive standard hospital care plus an oral dose of 400 mg or 800 mg/day of Brazilian green propolis for seven days, or standard care alone. The primary end point was the time to clinical improvement, defined as the length of hospital stay or oxygen therapy dependency duration. Secondary outcomes included acute kidney injury and need for intensive care or vasoactive drugs.

The length of hospital stay post-intervention was statistically shorter in both propolis groups than in the control group (lower dose, median 7 days versus 12 days; (95% confidence interval [CI] −6.23 to −0.07; p = 0.049) and higher dose, median 6 days versus 12 days (95% CI −7.00 to −1.09; p = 0.009). A lower rate of acute kidney injury than in the controls (4.8 vs 23.8%) was also reported in the high dose propolis group. No patient discontinued propolis treatment due to adverse events.

While further studies are called for, this study suggests the addition of propolis to standard hospital care procedures could have significant clinical benefits in some COVID-19 patients(13).

Other encouraging reports of late include in vitro inhibition of COVID-19 viral replication by Eqyptian propolis (an activity enhanced by liposomal encapsulation)(9), and inhibition of COVID-19 protease as well as angiotensin-converting enzyme-2 (a receptor for SARS-CoV-2 in the human body), by compounds derived from Indonesian propolis(14, 15). Molecular simulations also suggest that propolis flavonoids may inhibit viral spike fusion in host cells, and viral-host interactions that trigger the cytokine storm(16).

Anti-inflammatory

Hundreds of papers report immunomodulatory and anti-inflammatory activities for different types of propolis, including inhibition of COX-2 and nitric oxide synthesis, reduced levels of inflammatory cytokines, and antioxidant activities(17). A review of six clinical studies involving 406 participants, found a significant reduction in levels of inflammatory markers including serum CRP and TNF-alpha, following propolis intake(18).

In pre-clinical studies, propolis promoted immunoregulation of pro-inflammatory cytokines and exhibited several potential mechanisms to help to reduce the risk of a cytokine storm(10).

As effective anti-inflammatory concentrations of propolis seem significantly lower than antibacterial and antiviral ones, these studies suggest anti-inflammatory properties may be its most important feature(3, 19).

Use as an adjuvant treatment in autoimmune conditions such as asthma has received some clinical trial support (20, 21).

Antibacterial:

The first data published regarding the antibacterial activity of propolis extract dates back to 1980, in which sensitivity of Streptococcus species to propolis extract was reported(22). Since then propolis has been tested on more than 600 strains of bacteria, with encouraging findings(23). Greater activity has been measured against Gram-positive than Gram-negative bacteria, with antimicrobial activity varying depending on the region of the world from which the propolis was sourced.

Many novel antimicrobial compounds have been identified in propolis, several of which can help overcome antimicrobial resistance of multidrug resistant bacteria. Synergistic effect against bacterial strains such as Escherichia coli and Staphylococcus aureus have been reported for combinations with honey or other antibiotics(24).

A clinical trial involving the simultaneous admin of propolis and melatonin in patients with primary sepsis, is currently underway(25).

Dental applications–

The anti-inflammatory, antibacterial and antifungal properties of propolis also have many potential applications in dentistry, as alternatives to current antimicrobial and conventional agents(26-29).  Indications that have been supported by studies including clinical trials, include to heal dental surgical wounds, as an intracanal irrigant, a mouthwash or toothpaste, and for the treatment of periodontitis and gum inflammation, and denture stomatitis(29).

Wound healing:

One of the oldest traditional applications of propolis is its application to disinfect skin and to improve wound healing. Its widespread antimicrobial activities in addition to inhibitory effects on biofilm formation, and anti-inflammatory actions, are undoubtedly largely contributory.  Enhancement in the wound repair abilities of keratinocytes, has also been reported recently(30).

Most in vivo studies undertaken on different wound models suggest beneficial roles of propolis on experimental wound healing(31,32), although products and doses used have been variable.

A review of 5 clinical trials involving the use of propolis mouthwash in cancer therapy-induced oral mucositis, found it to be both effective and safe(33). Post-tonsillectomy pain and wound healing was also significantly improved following use of propolis orally and by gargle, in a Korean clinical trial involving 130 tonsillectomy and adenotonsillectomy patients(34).

A shorter healing time and improved symptom picture was reported for a 0.5% propolis cream compared to acyclovir 5% cream, in a Slovakian trial involving 198 patients with herpes labialis(35).

Mixing different propolis samples collected from different locations in Iraq resulted in superior antimicrobial and wound healing properties than measured in individual propolis(36).

Cancer-protective?

Most diterpenes isolated from propolis possess cytotoxic activities (37 Aminimoghadamfarouj, Nematolahi 2017), and a plethora of in vitro studies have documented cytotoxic effects of many different propolis extracts against various types of cancer. These include head and neck, lung, liver, brain (glioma), pancreas, kidney, prostate, skin (melanoma), breast, oral, esophagus, gastric, colorectal, and bladder cancers(37-42).

Propolis is likely to exhibit chemoprotective or anti-cancer effects due to the presence of phytochemicals with pro-apoptotic, cytotoxic, anti-proliferative, anti-metastatic, anti-invasive, anti-angiogenic and anti-genotoxic or anti-mutagenic properties along with antioxidant, immunomodulatory, and anti-inflammatory functions.

A recent review into evidence-based complementary medicines to support chemotherapy treatment of pancreatic cancer patients, concluded that integrated management offers the best patient outcome, and that propolis was one of 9 most promising natural treatment agents identified(43). Clinical studies are justified, into the use of propolis as an adjuvant alongside standard chemotherapy treatment for the treatment of various cancers(42).

Cardiac health:

A recent review documents numerous potentially useful pharmacological properties of propolis in terms of cardiac health(44). These include anti platelet aggregation, antioxidant and anti-inflammatory activities, which may protect against vascular endothelial and cardiomyocyte dysfunction, and potentially thrombus formation.  Further in vivo studies are however needed to confirm these beneficial effects in the prevention of cardiovascular diseases, and pre-clinical research to assess cardiovascular effects of the different types of propolis, would be useful(17, 45).

Diabetes:

Various animal studies have found improvement in insulin resistance and increased sensitivity to insulin following propolis administration(46). Improvement in glycaemic status and antioxidant enzymes, and reduction in insulin resistance, have been reported following propolis treatment at 1500mg a day for 8 weeks, in type 2 diabetic patients(47).

A recent trial involving 12 months treatment of chronic kidney disease patients with Brazilian green propolis extract at a dose of 500mg/day, reported a significant reduction in proteinuria(48). Another found topical propolis improved healing when used as an adjuvant treatment in the care of diabetic foot wounds(49).

Anti-inflammatory properties of propolis, are likely to contribute to its favourable effects in some diabetic patients, as inflammatory cytokine production in diabetic patients is increased

Other properties

While propolis can be used in these and other conditions, caution should be taken due to some allergic reactions in some patients.

Evidence is also becoming apparent of potentially protective effects against drug-induced nephrotoxicity and various neurological and psychiatric conditions, for both propolis and caffeic acid phenethyl ester(50, 51).

References:

  1. Dezmirean DS et al, Plants 2020; 10(1):22.
  2. Sforcin JM. J Ethnopharmacol 2007; 113(1):1-14.
  3. Al-Hariri M. Immune’s-boosting agent: Immunomodulation potentials of propolis. J Family Community Med. 2019 Jan-Apr;26(1):57-60. doi: 10.4103/jfcm.JFCM_46_18. PMID: 30697106; PMCID: PMC6335834.
  4. Debiaggi M, Tateo F, Pagani L, Luini M, Romero E. Effects of propolis flavonoids on virus infectivity and replication. Microbiologica. 1990 Jul;13(3):207-13. PMID: 2125682.
  5. Schnitzler P, Neuner A, Nolkemper S, Zundel C, Nowack H, Sensch KH, Reichling J. Antiviral activity and mode of action of propolis extracts and selected compounds. Phytother Res. 2010 Jan;24 Suppl 1:S20-8. doi: 10.1002/ptr.2868. Erratum in: Phytother Res. 2010 Apr;24(4):632. PMID: 19472427.
  6. Shimizu T, Hino A, Tsutsumi A, Park YK, Watanabe W, Kurokawa M. Anti-influenza virus activity of propolis in vitro and its efficacy against influenza infection in mice. Antivir Chem Chemother. 2008;19(1):7-13. doi: 10.1177/095632020801900102. PMID: 18610553.
  7. Soroy L, Bagus S, Yongkie IP, Djoko W. The effect of a unique propolis compound (Propoelix™) on clinical outcomes in patients with dengue hemorrhagic fever. Infect Drug Resist. 2014 Dec 9;7:323-9. doi: 10.2147/IDR.S71505. PMID: 25525372; PMCID: PMC4266269.
  8. Mojarab S, Shahbazzadeh D, Moghbeli M, Eshraghi Y, Bagheri KP, Rahimi R, Savoji MA, Mahdavi M. Immune responses to HIV-1 polytope vaccine candidate formulated in aqueous and alcoholic extracts of Propolis: Comparable immune responses to Alum and Freund adjuvants. Microb Pathog. 2020 Mar;140:103932. doi: 10.1016/j.micpath.2019.103932. Epub 2019 Dec 16. PMID: 31857237.
  9. Refaat H,  Mady FM, Sarhan HA, Rateb HS, Alaaeldin E. Optimization and evaluation of propolis liposomes as a promising therapeutic approach for COVID-19.  Int J Pharm . 2021 Jan 5;592:120028.
  10. Berretta AA, Silveira MAD, Cóndor Capcha JM, De Jong D. Propolis and its potential against SARS-CoV-2 infection mechanisms and COVID-19 disease: Running title: Propolis against SARS-CoV-2 infection and COVID-19. Biomed Pharmacother. 2020;131:110622. doi:10.1016/j.biopha.2020.110622
  11. Bachevski D, Damevska K, Simeonovski V, Dimova M. Back to the basics: Propolis and COVID-19. Dermatol Ther. 2020;33(4):e13780. doi:10.1111/dth.13780
  12. G.  The effect of propolis supplementation on clinical symptoms in patients with coronavirus (COVID-19): A structured summary of a study protocol for a randomised controlled trial. Trials . 2020 Dec 3;21(1):996.
  13. Silveira MAD, De Jong D, Berretta AA, et al. Efficacy of Brazilian green propolis (EPP-AF®) as an adjunct treatment for hospitalized COVID-19 patients: A randomized, controlled clinical trial. Biomed Pharmacother. 2021;138:111526. doi:10.1016/j.biopha.2021.111526.
  14. Sahlan M, Irdiani R, Flamandita D, et al. Molecular interaction analysis of Sulawesi propolis compounds with SARS-CoV-2 main protease as preliminary study for COVID-19 drug discovery. J King Saud Univ Sci. 2021;33(1):101234. doi:10.1016/j.jksus.2020.101234.
  15. Khayrani AC, Irdiani R, Aditama R, et al. Evaluating the potency of Sulawesi propolis compounds as ACE-2 inhibitors through molecular docking for COVID-19 drug discovery preliminary study. J King Saud Univ Sci. 2021;33(2):101297. doi:10.1016/j.jksus.2020.101297
  16. Ali AM, Kunugi H. Propolis, Bee Honey, and Their Components Protect against Coronavirus Disease 2019 (COVID-19): A Review of In Silico, In Vitro, and Clinical Studies. Molecules. 2021;26(5):1232. Published 2021 Feb 25. doi:10.3390/molecules26051232
  17. Braakhuis A. Evidence on the Health Benefits of Supplemental Propolis. Nutrients. 2019 Nov 8;11(11):2705.
  18. Jalali M, Ranjbar T, Mosallanezhad Z, Mahmoodi M, Moosavian SP, Ferns GA, Jalali R, Sohrabi Z. Effect of Propolis Intake on Serum C-Reactive Protein (CRP) and Tumor Necrosis Factor-alpha (TNF-α) Levels in Adults: A Systematic Review and Meta-Analysis of Clinical Trials.
    Complement Ther Med. 2020 May;50:102380.
  19. Governa P, Cusi MG, Borgonetti V, Sforcin JM, Terrosi C, Baini G, Miraldi E, Biagi M. Beyond the Biological Effect of a Chemically Characterized Poplar Propolis: Antibacterial and Antiviral Activity and Comparison with Flurbiprofen in Cytokines Release by LPS-Stimulated Human Mononuclear Cells. Biomedicines. 2019 Sep 21;7(4):73. doi: 10.3390/biomedicines7040073. PMID: 31546676; PMCID: PMC6966560.
  20. Khayyal MT, el-Ghazaly MA, el-Khatib AS, Hatem AM, de Vries PJ, el-Shafei S, Khattab MM. A clinical pharmacological study of the potential beneficial effects of a propolis food product as an adjuvant in asthmatic patients. Fundam Clin Pharmacol. 2003 Feb;17(1):93-102. doi: 10.1046/j.1472-8206.2003.00117.x. PMID: 12588635.
  21. Mirsadraee M, Azmoon B, Ghaffari S, Abdolsamadi A, Khazdair MR. Effect of Propolis on moderate persistent asthma: A phase two randomized, double blind, controlled clinical trial. Avicenna J Phytomed. 2021 Jan-Feb;11(1):22-31. PMID: 33628717; PMCID: PMC7885004.
  22. Meresta L., Meresta T. Effect of pH on bactericidal activity of propolis. Bull. Veterina. Inst. Pulawy. 1980;24:21–25.
  23. Przybyłek I, Karpiński TM. Antibacterial Properties of Propolis. Molecules. 2019 May 29;24(11):2047. doi: 10.3390/molecules24112047. PMID: 31146392; PMCID: PMC6600457.
  24. Almuhayawi MS. Propolis as a novel antibacterial agent. Saudi J Biol Sci. 2020 Nov;27(11):3079-3086. doi: 10.1016/j.sjbs.2020.09.016. Epub 2020 Sep 14. PMID: 33100868; PMCID: PMC7569119.
  25. Pahlavani N, Sedaghat A, Bagheri Moghaddam A, Mazloumi Kiapey SS, Gholizadeh Navashenaq J, Jarahi L, Reazvani R, Norouzy A, Nematy M, Safarian M, Ghayour-Mobarhan M. Effects of propolis and melatonin on oxidative stress, inflammation, and clinical status in patients with primary sepsis: Study protocol and review on previous studies. Clin Nutr ESPEN. 2019 Oct;33:125-131. doi: 10.1016/j.clnesp.2019.06.007. Epub 2019 Jul 5. PMID: 31451248.
  26. Bretz WA, Paulino N, Nör JE, Moreira A. The effectiveness of propolis on gingivitis: a randomized controlled trial. J Altern Complement Med. 2014;20(12):943-948. doi:10.1089/acm.2013.0431
  27. Pundir AJ, Vishwanath A, Pundir S, Swati M, Banchhor S, Jabee S. One-stage Full Mouth Disinfection Using 20% Propolis Hydroalcoholic Solution: A Clinico-microbiologic Study. Contemp Clin Dent. 2017;8(3):416-420. doi:10.4103/ccd.ccd_544_17      
  28. Skoskiewicz-Malinowska K, Kaczmarek U, Malicka B, Walczak K, Zietek M. Application of Chitosan and Propolis in Endodontic Treatment: A Review. Mini Rev Med Chem. 2017;17(5):410-434. doi: 10.2174/1389557516666160418122510. PMID: 27087464.
  29. Zulhendri F, Felitti R, Fearnley J, Ravalia M. The use of propolis in dentistry, oral health, and medicine: A review. J Oral Biosci. 2021 Mar;63(1):23-34. doi: 10.1016/j.job.2021.01.001. Epub 2021 Jan 16. PMID: 33465498.
  30. Martinotti S, Pellavio G, Laforenza U, Ranzato E. Propolis Induces AQP3 Expression: A Possible Way of Action in Wound Healing. Molecules. 2019 Apr 19;24(8):1544. doi: 10.3390/molecules24081544. PMID: 31010117; PMCID: PMC6515181.
  31. Abu-Seida AM. Effect of Propolis on Experimental Cutaneous Wound Healing in Dogs. Vet Med Int. 2015;2015:672643. doi: 10.1155/2015/672643. Epub 2015 Dec 13. PMID: 26783495; PMCID: PMC4691486.
  32. Oryan A, Alemzadeh E, Moshiri A. Potential role of propolis in wound healing: Biological properties and therapeutic activities. Biomed Pharmacother. 2018 Feb;98:469-483. doi: 10.1016/j.biopha.2017.12.069. Epub 2017 Dec 27. PMID: 29287194.
  33. Kuo CC, , Wang R-H 2Wang H-H, Li C-H.. Meta-analysis of randomized controlled trials of the efficacy of propolis mouthwash in cancer therapy-induced oral mucositis. Support Care Cancer. 2018 Dec;26(12):4001-4009
  34. Moon JH, Lee MY, Chung YJ, Rhee CK, Lee SJ. Effect of Topical Propolis on Wound Healing Process After Tonsillectomy: Randomized Controlled Study. Clin Exp Otorhinolaryngol. 2018 Jun;11(2):146-150. doi: 10.21053/ceo.2017.00647. Epub 2017 Dec 28. PMID: 29665628; PMCID: PMC5951064.
  35. Jautová J, Zelenková H, Drotarová K, Nejdková A, Grünwaldová B, Hladiková M. Lip creams with propolis special extract GH 2002 0.5% versus aciclovir 5.0% for herpes labialis (vesicular stage) : Randomized, controlled double-blind study. Lippencreme mit 0,5 % Propolis-Spezialextrakt GH 2002 versus 5 % Aciclovir bei Herpes labialis (Bläschenstadium) : Randomisierte, kontrollierte Doppelblindstudie. Wien Med Wochenschr. 2019;169(7-8):193-201. doi:10.1007/s10354-018-0667-6.
  36. Al-Waili N. Mixing two different propolis samples potentiates their antimicrobial activity and wound healing property: A novel approach in wound healing and infection. Vet World. 2018 Aug; 11(8): 1188–1195.
  37. Aminimoghadamfarouj N, Nematollahi A. Propolis Diterpenes as a Remarkable Bio-Source for Drug Discovery Development: A Review. Int J Mol Sci. 2017;18(6):1290. Published 2017 Jun 17. doi:10.3390/ijms18061290
  38. Chen WT, Sun YK, Lu CH, Chao CY. Thermal cycling as a novel thermal therapy to synergistically enhance the anticancer effect of propolis on PANC‑1 cells. Int J Oncol. 2019;55(3):617-628. doi:10.3892/ijo.2019.4844
  39. Asgharpour F, Moghadamnia AA, Zabihi E, et al. Iranian propolis efficiently inhibits growth of oral streptococci and cancer cell lines. BMC Complement Altern Med. 2019;19(1):266. Published 2019 Oct 11. doi:10.1186/s12906-019-2677-3.
  40. Demir S, Aliyazicioglu Y, Turan I, Misir S, Mentese A, Yaman SO, Akbulut K, Kilinc K, Deger O. Antiproliferative and proapoptotic activity of Turkish propolis on human lung cancer cell line. Nutr Cancer. 2016;68(1):165-72. doi: 10.1080/01635581.2016.1115096. Epub 2015 Dec 23. PMID: 26700423.
  41. Zabaiou N, Fouache A, Trousson A, Baron S, Zellagui A, Lahouel M, Lobaccaro JA. Biological properties of propolis extracts: Something new from an ancient product. Chem Phys Lipids. 2017 Oct;207(Pt B):214-222. doi: 10.1016/j.chemphyslip.2017.04.005. Epub 2017 Apr 12. PMID: 28411017.
  42. Chiu HF, Han YC, Shen YC, Golovinskaia O, Venkatakrishnan K, Wang CK. Chemopreventive and Chemotherapeutic Effect of Propolis and Its Constituents: A Mini-review. J Cancer Prev. 2020;25(2):70-78. doi:10.15430/JCP.2020.25.2.70
  43. Jentzsch V et al, Cancers (Basel). 2020 Oct 23;12(11):3096
  44. Silva H, Francisco R, Saraiva A, Francisco S, Carrascosa C, Raposo A. The Cardiovascular Therapeutic Potential of Propolis-A Comprehensive Review. Biology (Basel). 2021;10(1):27. Published 2021 Jan 4. doi:10.3390/biology10010027
  45. Bojić M, Antolić A, Tomičić M, Debeljak Ž, Maleš Ž. Propolis ethanolic extracts reduce adenosine diphosphate induced platelet aggregation determined on whole blood. Nutr J. 2018;17(1):52. Published 2018 May 14. doi:10.1186/s12937-018-0361-y
  46. Pahlavani N, Malekahmadi M, Firouzi S, Rostami D, Sedaghat A, Moghaddam AB, Ferns GA, Navashenaq JG, Reazvani R, Safarian M, Ghayour-Mobarhan M. Molecular and cellular mechanisms of the effects of Propolis in inflammation, oxidative stress and glycemic control in chronic diseases. Nutr Metab (Lond). 2020 Aug 12;17:65. doi: 10.1186/s12986-020-00485-5. PMID: 32817750; PMCID: PMC7425411.
  47. Afsharpour FJavadi M, Hashemipour S, Koushan Y, Haghighian HK. Propolis supplementation improves glycemic and antioxidant status in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled study. Complement Ther Med. 2019 Apr;43:283-288
  48. Silveira MAD, Teles F, Berretta AA, et al. Effects of Brazilian green propolis on proteinuria and renal function in patients with chronic kidney disease: a randomized, double-blind, placebo-controlled trial. BMC Nephrol. 2019;20(1):140. Published 2019 Apr 25. doi:10.1186/s12882-019-1337-7.
  49. Mujica V, Orrego R, Fuentealba R, Leiva E, Zúñiga-Hernández J. Propolis as an Adjuvant in the Healing of Human Diabetic Foot Wounds Receiving Care in the Diagnostic and Treatment Centre from the Regional Hospital of Talca. J Diabetes Res. 2019;2019:2507578. Published 2019 Sep 12. doi:10.1155/2019/2507578
  50. Farooqui T, Farooqui AA. Beneficial effects of propolis on human health and neurological diseases. Front Biosci (Elite Ed). 2012 Jan 1;4:779-93. doi: 10.2741/418. PMID: 22201913.
  51. Menezes da Silveira CCS, Luz DA, da Silva CCS, Prediger RDS, Martins MD, Martins MAT, Fontes-Júnior EA, Maia CSF. Propolis: A useful agent on psychiatric and neurological disorders? A focus on CAPE and pinocembrin components. Med Res Rev. 2021 Mar;41(2):1195-1215. doi: 10.1002/med.21757. Epub 2020 Nov 11. PMID: 33174618.

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